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Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial.
Lancet (London, England)· 2023-01-28· rct
Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, Najib M Rahman, Gail Hayward, Duncan B Richards, Jienchi Dorward, David M Lowe, Joseph F Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S Nguyen-Van-Tam, Mahendra G Patel, Benjamin R Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P B Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A Detry, Christina T Saunders, Mark Fitzgerald, Nicholas S Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D Jani, Nigel D Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little, Unknown
Stage: unknownIntegrity: okDOI: 10.1016/s0140-6736(22)02597-1PMID: 36566761PMCID: PMC9779781
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Study design
Verified findings
numeric_findings[2]
{"unit":null,"label":"reported_value","value_text":"8"}
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FINDINGS · FINDINGS:S001
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numeric_findings[3]
{"unit":null,"label":"reported_value","value_text":"12"}
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FINDINGS · FINDINGS:S002
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numeric_findings[4]
{"unit":null,"label":"reported_value","value_text":"56"}
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FINDINGS · FINDINGS:S003
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population
{"description":"The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the community at increased risk of mo","sample_size":null,"exclusion_summary":null,"inclusion_summary":null}
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BACKGROUND · BACKGROUND:S001
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Limitations & not reported
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- extension.rct_extension.randomization_method
- extension.rct_extension.sample_size_arms
- intervention
- key_results
- limitations
- primary_outcome
- safety_findings
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